IgG subclasses Pneumococcal Pneumovax®23 Primary immunodeficiency Vaccine response.īonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP, Jr, et al. Male sex and atopy were associated with lower aggregate responses. Serotype-specific IgG responses to Pneumovax®23 were greater in patients with subnormal IgG1 than subnormal IgG3. Regression on aggregate response revealed lower response with male sex (odds ratio 0.09 ) and atopy (0.17 ). Aggregate responders were: subnormal IgG1, 54% IgG3, 46% and IgG1 + IgG3, 46%. Response rates decreased with increasing age. Subnormal IgG3 non-responders had higher responses to serotypes 1, 3, 8, 9, 12, 14, 19, 51, and 56. Subnormal IgG3 responders had lower responses to serotypes 1, 4, 12, 23, 26, and 51. All subnormal IgG1 + IgG3 non-responders responded to serotypes 8, 9 and 26, unlike other non-responders. The median post-vaccination summated concentration of serotype-specific IgG was higher in patients with subnormal IgG1 than subnormal IgG3 (responders and non-responders). Median days between pre- and post-Pneumovax®23 testing was 33 (range 19-158). There were 59 patients (mean age 44 ± 13 (SD) years 83.1% women). We compared patients with and without serotype-specific responses and performed logistic regression on aggregate responses using: age male sex body mass index autoimmune condition(s) atopy other allergies subnormal IgGSc immunophenotypes IgA and IgM. We defined response as serotype-specific IgG > 1.3 μg/mL and aggregate response as IgG > 1.3 μg/mL for ≥70% of all serotypes tested. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations.
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